Mundane: A game where you fight drug dealers.
Edgy: A game that shows protagonists doing drugs.
Over the top: Making a game where the main character deals and does drugs.
Saints Row 2: A game where the main character uses drugs and alcohol as healing items.
Shamus Young is a programmer and writer by trade, videogame nitpicker by inclination. If you have the patience for more of his ramblings, they can be found at ShamusYoung.com.