Agro (Shadow of the Colossus)
First mentioned by The Almighty Aardvark
Wander's loyal horse from Shadow of the Colossus definitely deserves a spot on this list. Not only does she use her speed to help Wander keep up with or escape enemies, she even appears to sacrifice herself for Wander on the bridge to the final Colossus. Although she does survive, she's limping on injured hind leg when next we see her. One little tip you may not know: if you start a new Shadow of the Colossus game with an Ico save game on your memory card, the marking on Agro's head will change to an "I" shaped patch matching the Ico logo.