The science-fiction fantasy game Shadowrun Returns is another strong entry into the isometric RPG genre. after you've chosen a class, you'll go forth into a well-designed world that's based entirely on the tabletop campaign setting. You're trying to find out who killed your friend and former accomplice so that you can earn a hefty reward. Along the way, you'll earn Karma that can be used to boost your characters' abilities, and you can even hire up to three other "runners" to aid you in your mission. As good as the initial game and expansions are, the included mod tools mean that there will be even more great content to explore.
You can check it out on GOG.com.