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Sword Art Online
Sword Art Online is already a game-friendly setting, since it takes place within an MMO. The light novel and anime series follow virtual reality MMO players who are trapped online by the game's creator, and face a real death if their characters are killed. While a few action titles explored alternate storylines, the ideal direction would be a meta Sword Art MMO where "NPCs" behave like other players trapped in-game. Your party's actions would determine whether Sword Art's protagonists are freed, killed, or trapped forever. It would certainly be experimental, but given Sword Art Online's popularity, the approach might be a successful one.