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Nausicaa of the Valley of the Wind
Nausicaa of the Valley of the Wind is one of the more unusual post-apocalyptic films out there, but it's positive message helped it stand out as a seminal anti-war anime. Set years after a nuclear war, the game follows Nausicaa as she attempts to defuse a conflict between human soldiers and giant mutant insects that inhabit a radioactive jungle. It's had a few shooters in the past, but an RPG that emphasizes peaceful approaches to unlock the best ending might be a great fit here.