Cazador were only annoying 'cause there was a nest of them directly north of the starting town in New Vegas.
Later in the game they're cake.

No Cliffracers?

Silentpony:
Cazador were only annoying 'cause there was a nest of them directly north of the starting town in New Vegas.
Later in the game they're cake.

So many people bitch about NV being overly difficult starting off because they didn't listen to the NPCs in Goodsprings.

Also, no Rabid Stalkers from Borderlands 2? Those things were pure misery.

Ravinoff:

Silentpony:
Cazador were only annoying 'cause there was a nest of them directly north of the starting town in New Vegas.
Later in the game they're cake.

So many people bitch about NV being overly difficult starting off because they didn't listen to the NPCs in Goodsprings.

Also, no Rabid Stalkers from Borderlands 2? Those things were pure misery.

Right? Everyone is Goodsprings says don't go north, if you go north there are a bunch of warning signs and road signs saying 'GIANT FUCKING BUGS!'
And like everyone I thought I was too big for my shoes, tried to shoot them at range, and was turned to mince instantly. And then I went South.

I mean for fucks sake, even Yahtzee talks about dying to giant killer flies in his ZP video.

Fallout 4's suicidal super mutants. When I hear that beep beep beep, I always freak out if my critical meter is full or not, then despair when a headshot only takes off a sliver.

Wrex Brogan:

Silentpony:
Cazador were only annoying 'cause there was a nest of them directly north of the starting town in New Vegas.
Later in the game they're cake.

Hell even in early game they're not that bad. Just VATS their wings or use some dynamite... and if you have the Ultimate Edition you get a god-damn Grenade Launcher right from the start. Easy pickings.

Now Legion/NCR assassins. THOSE guys are a pain in the arse. Frequent spawns, follow you even when you're stealthed, high damage outputs, scale with your level so they get super resilient... waaaay more annoying than Cazadores. Plus because of how they spawn if you fast-travel too much you can have 3+ squads hunting you down.

Aetrion:
No Cliffracers?

Maybe he's successfully bleached them from his mind - lord knows I've certainly tried to.

Morrowind: The only game I've ever dreaded getting to level 8.

Cliff Racers were the worst not just because they were terrible enemies, but Morrowind made you miss all the time. The game wasn't designed with misses in mind. All round poor design choices.

008Zulu:
Fallout 4's suicidal super mutants. When I hear that beep beep beep, I always freak out if my critical meter is full or not, then despair when a headshot only takes off a sliver.

Those guys are assholes, but you know what really gets me in FO4? Baby Mirelurks.
Those irritating little bastards are just going to nip at your heels like some stupid crab based version of a chihuahua, being impossible to hit with gunfire outside of VATS and not really worth wasting ammo on, so you end up whirling round in a circle flailing wildly with your melee weapon until the suicidally stupid little fuckers are all dead.
They're shit, they're not a threat or a challenge, they are literally just there as an annoyance. Fuckin dumbass crab woodlouse things. Hate 'em.

Eh, most of those are just a certain type of challenge. Annoying to me is something that either takes too long, comes too often or has to be defeated in tedious way. You know, something that makes the general experience worse, like those bloody ghosts in Metroid Prime.

I'm also going to mention Cliffracers. Bloody things often come out of nowhere and start pecking at my head.
In fact the only on this list I'd consider genuinely annoying is Zubat. The rest are either from games I haven't played, didn't get far enough to encounter (wheel skeleton), or found more of a challenge than an annoyance. I mean from the brief time I played WoW, I found the Murlocs only showed up in specific areas so they were easy to avoid and were quite easy to kill.

I always found the terror drones the soviets had in red alert 2 annoying as hell.

Ehh, needs cliffracers and the black headcrabs weren't more agile. If anything they were slower, but they were also much tougher.

I knew the Medusa heads would be on this list, and I was not disappointed.
Here's an annoying video game enemy: the Boos from the old side-scrolling Super Mario games. I couldn't kill them with jumping on their heads or fireballs, but when I was able to punch them to death in Mario 64, it felt Soooooooo good.

008Zulu:
Fallout 4's suicidal super mutants. When I hear that beep beep beep, I always freak out if my critical meter is full or not, then despair when a headshot only takes off a sliver.

Go for the right arm. One hit sets off the nuke prematurely.

truckspond:

Go for the right arm. One hit sets off the nuke prematurely.

I would, but I need the mini nuke they carry.

Aw man, but Murlocs get the best questlines in the later expansions though!

Blackknight7W:
I always found the terror drones the soviets had in red alert 2 annoying as hell.

They got worse in Red Alert 3, they got a secondary firing mode called the Electrostasis Ray, which is a sustained firing mode that prevents a mechanical unit from moving as long as it's targeted. So you could use the Electrostasis and follow up with V4 or Dreadnaught bombardment, or roll a second Terror Drone in to attack the vehicle. It can still fire, but otherwise is pretty boned.

No Cliff Racers, okay.

And Dragons in Skyrim are just Cliff Racers on steroids. I would have gladly taken a handful of lenghty, well scripted and memorable dragon fights than the boring ass chore they were made out to be. Gothic 2's dragons back in the day were all the same, just with color palette swaps, but atleast they got the "this is it" feeling right.

Ravinoff:
Also, no Rabid Stalkers from Borderlands 2? Those things were pure misery.

These guys are my number 1 vote. First to phaselock. First to die. I know you can dodge side to side when they are lunging to let them fly by. But it always seems to just be backup-bite-backup-bite-backup-bite.

008Zulu:

truckspond:

Go for the right arm. One hit sets off the nuke prematurely.

I would, but I need the mini nuke they carry.

The most annoying thing I found about Suiciders is since shooting the Mini Nuke counts as an indirect kill and Fallout 4 doesn't count indirect kills for gaining experience it's doubly pointless to shoot the Mini Nukes to kill them. Suiciders don't carry any loot either so by shooting the Nuke you get nothing out of fighting them besides getting rid of them.